Contryphan-Am (P01270) Protein Card

General Information
Name Contryphan-Am
Alternative name(s) Am975
Organism Conus amadis
Organism region Indo-Pacific
Organism diet molluscivorous
Protein Type Wild type
Protein precursor Contryphan-Am precursor (8373)
Notes According to Sabareesh et al. (2006), Contryphan-Am inhibits voltage-gated calcium channels.

Classification
Conopeptide class contryphan
Gene superfamily O2 superfamily
Pharmacological family omega conotoxin

Sequence
GCOwDPWC(nh2)
Modified residues
positionsymbolname
3O4-Hydroxyproline
4wD-tryptophan
9nh2C-term amidation
Sequence evidence protein level
Average Mass 976.09
Monoisotopic Mass 975.34
Isoelectric Point 2.19
Extinction Coefficient [280nm] 11000.00

References
Gowd,K.H., Sabareesh,V., Sudarslal,S., Iengar,P., Franklin,B., Fernando,A., Dewan,K., Ramaswami,M., Sarma,S.P., Sikdar,S., Balaram,P. and Krishnan,K.S. (2005) Novel peptides of therapeutic promise from Indian Conidae Ann. N. Y. Acad. Sci. 1056:462
Sabareesh,V., Gowd,K.H., Ramasamy,P., Sudarslal,S., Krishnan,K.S., Sikdar,S.K. and Balaram,P. (2006) Characterization of contryphans from Conus loroisii and Conus amadis that target calcium channels Peptides 27:2647-2654
Thakur,S.S. and Balaram,P. (2007) Rapid mass spectral identification of contryphans. Detection of characteristic peptide ions by fragmentation of intact disulfide-bonded peptides in crude venom. Rapid Commun. Mass Spectrom. 21:3420-3426
Vijayasarathy, M. and Balaram, P. (2019) Cone snail prolyl-4-hydroxylase α-subunit sequences derived from transcriptomic data and mass spectrometric analysis of variable proline hydroxylation in C. amadis venom Journal of proteomics 194:37-48
Vijayasarathy,M., Basheer,S.M., Franklin,J.B. and Balaram,P. (2017) Contryphan Genes and Mature Peptides in the Venom of Nine Cone Snail Species by Transcriptomic and Mass Spectrometric Analysis. J. Proteome Res. 16:763-772

Internal links
Protein Precursor Contryphan-Am precursor (8373)
Nucleic acids
Structure

External links
UniProtKB/Swiss-Prot P0C248
Ncbi 2M6G_A, KT713755, 2M6H_A, P0C248

Tools