Contryphan-Am (P01270) Protein Card

General Information
Name Contryphan-Am
Alternative name(s) Am975
Organism Conus amadis
Organism region Indo-Pacific
Organism diet molluscivorous
Protein Type Wild type

Classification
Conopeptide class contryphan
Gene superfamily
Pharmacological family

Sequence
GCOwDPWC(nh2)
Modified residues
positionsymbolname
3O4-Hydroxyproline
4wD-tryptophan
9nh2C-term amidation
Sequence evidence protein level
Average Mass 976.09
Monoisotopic Mass 975.34
Isoelectric Point 2.19
Extinction Coefficient [280nm] 11000.00

References
Gowd,K.H., Sabareesh,V., Sudarslal,S., Iengar,P., Franklin,B., Fernando,A., Dewan,K., Ramaswami,M., Sarma,S.P., Sikdar,S., Balaram,P. and Krishnan,K.S. (2005) Novel peptides of therapeutic promise from Indian Conidae Ann. N. Y. Acad. Sci. 1056:462
Sabareesh,V., Gowd,K.H., Ramasamy,P., Sudarslal,S., Krishnan,K.S., Sikdar,S.K. and Balaram,P. (2006) Characterization of contryphans from Conus loroisii and Conus amadis that target calcium channels Peptides 27:2647-2654

Internal links
Nucleic acids
Structure Solution structure of cis(C2-P3) trans (D5-P6) form of lO959 in water
Solution structure of trans(C2-P3) trans (D5-P6) of LO959 in methanol

External links
UniProtKB/Swiss-Prot P0C248
Ncbi P0C248, 2M6G_A, 2M6H_A

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