Contryphan-In (P01271) Protein Card

General Information
Name Contryphan-In
Alternative name(s) Contryphan In936
Organism Conus inscriptus
Organism region Indo-Pacific
Organism diet vermivorous
Protein Type Wild type

Classification
Conopeptide class contryphan
Gene superfamily
Pharmacological family

Sequence
GCVlYPWC(nh2)
Modified residues
positionsymbolname
4lD-leucine
9nh2C-term amidation
Sequence evidence protein level
Average Mass 937.14
Monoisotopic Mass 936.40
Isoelectric Point 8.09
Extinction Coefficient [280nm] 6990.00

References
Gowd,K.H., Sabareesh,V., Sudarslal,S., Iengar,P., Franklin,B., Fernando,A., Dewan,K., Ramaswami,M., Sarma,S.P., Sikdar,S., Balaram,P. and Krishnan,K.S. (2005) Novel peptides of therapeutic promise from Indian Conidae Ann. N. Y. Acad. Sci. 1056:462
Sonti,R., Gowd,K.H., Rao,K.N., Ragothama,S., Rodriguez,A., Perez,J.J. and Balaram,P. (2013) Conformational diversity in contryphans from Conus venom: cis-trans isomerisation and aromatic/proline interactions in the 23-membered ring of a 7-residue peptide disulfide loop. Chemistry 19:15175-15189

Internal links
Nucleic acids
Structure NMR solution structure of cis (minor) form of In936 in water
NMR solution structure of trans (major) form of In936 in water
NMR solution structure of cis (minor) form of In936 in Methanol
NMR solution structure of trans (major) form of In936 in Methanol

External links
UniProtKB/Swiss-Prot P0C249
Ncbi P0C249, 2M6F_A, 2M6E_A, 2M6D_A, 2M6C_A

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