Contryphan-Vn (P01309) Protein Card

General Information
Name Contryphan-Vn
Organism Conus ventricosus
Organism region Eastern Atlantic and Mediterranean
Organism diet molluscivorous
Protein Type Wild type

Classification
Conopeptide class contryphan
Gene superfamily
Pharmacological family

Sequence
GDCPwKPWC(nh2)
Modified residues
positionsymbolname
5wD-tryptophan
10nh2C-term amidation
Sequence evidence protein level
Average Mass 1088.26
Monoisotopic Mass 1087.44
Isoelectric Point 7.00
Extinction Coefficient [280nm] 11000.00

Synthetic variants
Contryphan-Vn [W8S](nh2)CSPKwPCDG

References
Massilia,G.R., Schinina,M.E., Ascenzi,P. and Polticelli,F. (2001) Contryphan-Vn: a novel peptide from the venom of the Mediterranean snail Conus ventricosus Biochem. Biophys. Res. Commun. 288:908-913
Massilia,G.R., Eliseo,T., Grolleau,F., Lapied,B., Barbier,J., Bournaud,R., Molgo,J., Cicero,D.O., Paci,M., Schinina,M.E., Ascenzi,P. and Polticelli,F. (2003) Contryphan-Vn: a modulator of Ca2+-dependent K+ channels Biochem. Biophys. Res. Commun. 303:238-246
Eliseo,T., Cicero,D.O., Romeo,C., Schinina,M.E., Massilia,G.R., Polticelli,F., Ascenzi,P. and Paci,M. (2004) Solution structure of the cyclic peptide contryphan-Vn, a Ca2+-dependent K+ channel modulator Biopolymers 74:189-198

Internal links
Nucleic acids
Structure SOLUTION STRUCTURE OF CONTRYPHAN-VN

External links
UniProtKB/Swiss-Prot P83047
Ncbi 1NXN_A, P83047

Tools