Contryphan-R precursor (P01310) Protein Card

General Information
Name Contryphan-R precursor
Organism Conus radiatus
Organism region Indo-Pacific
Organism diet piscivorous
Protein Type Precursor

Classification
Conopeptide class contryphan
Gene superfamily O2 superfamily
Pharmacological family

Sequence
MGKLTILVLVAAVLLSAQVMVQG
DGDQPADRNAVPRDDNPG
GASGKFMNVLRRS
GCPWEPWC
G
Sequence region
[1-23]signal sequence
[55-62]mature peptideContryphan-R

References
Jimenez,E.C., Craig,A.G., Watkins,M., Hillyard,D.R., Gray,W.R., Gulyas,J., Rivier,J.E., Cruz,L.J. and Olivera,B.M. (1997) Bromocontryphan: post-translational bromination of tryptophan Biochemistry 36:989-994
Jimenez,E.C., Olivera,B.M., Gray,W.R. and Cruz,L.J. (1996) Contryphan is a D-tryptophan-containing Conus peptide J. Biol. Chem. 271:28002-28005
Pallaghy,P.K., Melnikova,A.P., Jimenez,E.C., Olivera,B.M. and Norton,R.S. (1999) Solution structure of contryphan-R, a naturally occurring disulfide-bridged octapeptide containing D-tryptophan: comparison with protein loops Biochemistry 38:11553-11559
Pallaghy,P.K., He,W., Jimenez,E.C., Olivera,B.M. and Norton,R.S. (2000) Structures of the contryphan family of cyclic peptides. Role of electrostatic interactions in cis-trans isomerism Biochemistry 39:12845-12852

Internal links
Nucleic acids
Structure

External links
UniProtKB/Swiss-Prot P58786
Ncbi P58786

Tools