Conorfamide-Sr1 (P01317) Protein Card

General Information
Name Conorfamide-Sr1
Alternative name(s) CNF-Sr1
Organism Conus spurius
Organism region Western Atlantic and Caribbean
Organism diet vermivorous
Protein Type Wild type
Notes Espino et al.2018 reported that Conorfamide-Sr1 against human MRGPRX1 at 10 ┬ÁM is inactive, but active against mouse MRGPRC11.

Classification
Conopeptide class conorfamide
Gene superfamily
Pharmacological family

Sequence
GPMGWVPVFYRF(nh2)
Modified residues
positionsymbolname
13nh2C-term amidation
Sequence evidence protein level
Average Mass 1454.76
Monoisotopic Mass 1453.73
Isoelectric Point 11.16
Extinction Coefficient [280nm] 6990.00

References
Maillo,M., Aguilar,M.B., Lopez-Vera,E., Craig,A.G., Bulaj,G., Olivera,B.M. and Heimer de la Cotera,E.P. (2002) Conorfamide, a Conus venom peptide belonging to the RFamide family of neuropeptides Toxicon 40:401-407
Espino, S.S., Robinson, S.D., Safavi-Hemami, H., Gajewiak, J., Yang, W., Olivera, B.M. and Liu, Q. (2018) Conopeptides promote itch through human itch receptor hMgprX1 Toxicon 154:28-34

Internal links
Nucleic acids
Structure

External links
UniProtKB/Swiss-Prot P58805
Ncbi P58805

Tools