Contryphan-Sm (P01318) Protein Card

General Information
Name Contryphan-Sm
Organism Conus stercusmuscarum
Organism region Indo-Pacific
Organism diet piscivorous
Protein Type Wild type
Protein precursor Contryphan-Sm precursor (1311)

Classification
Conopeptide class contryphan
Gene superfamily O2 superfamily
Pharmacological family

Sequence
GCOwQPWC(nh2)
Modified residues
positionsymbolname
3O4-Hydroxyproline
4wD-tryptophan
9nh2C-term amidation
Sequence evidence protein level
Average Mass 988.12
Monoisotopic Mass 987.36
Isoelectric Point NA
Extinction Coefficient [280nm] 11000.00

References
Pallaghy,P.K., He,W., Jimenez,E.C., Olivera,B.M. and Norton,R.S. (2000) Structures of the contryphan family of cyclic peptides. Role of electrostatic interactions in cis-trans isomerism Biochemistry 39:12845-12852
Jacobsen,R., Jimenez,E.C., Grilley,M., Watkins,M., Hillyard,D., Cruz,L.J. and Olivera,B.M. (1998) The contryphans, a D-tryptophan-containing family of Conus peptides: interconversion between conformers J. Pept. Res. 51:173-179
Bhatia,S., Kil,Y.J., Ueberheide,B., Chait,B.T., Tayo,L., Cruz,L., Lu,B., Yates,J.R. 3rd. and Bern,M. (2012) Constrained de novo sequencing of conotoxins. J. Proteome Res. 11:4191-4200

Internal links
Protein Precursor Contryphan-Sm precursor (1311)
Nucleic acids
Structure Nmr Structure Of Contryphan-Sm Cyclic Peptide (Major Form- Cis)
Nmr Structure Of Contryphan-Sm Cyclic Peptide (Minor Form- Trans)

External links
Ncbi 1DFZ_A, 1DFY_A

Tools