GIC (P00132) Protein Card

General Information
Name GIC
Alternative name(s) G1c
Organism Conus geographus (Geography cone)
Organism region Indo-Pacific
Organism diet piscivorous
Protein Type Wild type
Protein precursor GIC precursor (97)

Classification
Conopeptide class conotoxin
Gene superfamily A superfamily
Cysteine framework I
Pharmacological family alpha conotoxin

Sequence
GCCSHPACAGNNQHIC(nh2)
Modified residues
positionsymbolname
17nh2C-term amidation
Sequence evidence nucleic acid level
Average Mass 1609.78
Monoisotopic Mass 1608.58
Isoelectric Point 8.42
Extinction Coefficient [280nm] NA

Activity

IC50: Nicotinic acetylcholine receptors

TargetOrganismIC50AgonistRef
α1β1δεH. sapiens>100uM10uM AchMcIntosh,J.M. et al. (2002)
α3β2H. sapiens1.1nM50uM AchMcIntosh,J.M. et al. (2002)
α3β4H. sapiens755nM50uM AchMcIntosh,J.M. et al. (2002)
α4β2H. sapiens309nM50uM AchMcIntosh,J.M. et al. (2002)

References
McIntosh,J.M., Dowell,C., Watkins,M., Garrett,J.E., Yoshikami,D. and Olivera,B.M. (2002) Alpha-conotoxin GIC from Conus geographus, a novel peptide antagonist of nicotinic acetylcholine receptors J. Biol. Chem. 277:33610-33615
Chi,S.W., Kim,D.H., Olivera,B.M., McIntosh,J.M. and Han,K.H. (2004) Solution conformation of alpha-conotoxin GIC, a novel potent antagonist of alpha3beta2 nicotinic acetylcholine receptors Biochem. J. 380:347-352

Internal links
Protein Precursor GIC precursor (97)
Nucleic acids
Structure SOLUTION CONFORMATION OF ALPHA-CONOTOXIN GIC
Crystal structure of Ac-AChBP in complex with conotoxin GIC

External links
Ncbi 1UL2_A

Tools