Contryphan-R (P01372) Protein Card

General Information
Name Contryphan-R
Alternative name(s) Bromocontryphan-R
Organism Conus radiatus
Organism region Indo-Pacific
Organism diet piscivorous
Protein Type Wild type
Protein precursor Contryphan-R precursor (1310)
Notes "Stiff-tail" syndrome in mice

Classification
Conopeptide class contryphan
Gene superfamily O2 superfamily
Pharmacological family

Sequence
GCOwEP(BTr)C(nh2)
Modified residues
positionsymbolname
3O4-Hydroxyproline
4wD-tryptophan
7BTrBromotryptophan
9nh2C-term amidation
Sequence evidence protein level
Average Mass 1068.00
Monoisotopic Mass 1066.26
Isoelectric Point 1.75
Extinction Coefficient [280nm] 5500.00

Synthetic variants
Contryphan-R [Des-Gly1](nh2)CWPQwOC
Cyclic contryphan(nh2)CKPNyOCG

References
Jimenez,E.C., Craig,A.G., Watkins,M., Hillyard,D.R., Gray,W.R., Gulyas,J., Rivier,J.E., Cruz,L.J. and Olivera,B.M. (1997) Bromocontryphan: post-translational bromination of tryptophan Biochemistry 36:989-994
Jimenez,E.C., Olivera,B.M., Gray,W.R. and Cruz,L.J. (1996) Contryphan is a D-tryptophan-containing Conus peptide J. Biol. Chem. 271:28002-28005
Pallaghy,P.K., Melnikova,A.P., Jimenez,E.C., Olivera,B.M. and Norton,R.S. (1999) Solution structure of contryphan-R, a naturally occurring disulfide-bridged octapeptide containing D-tryptophan: comparison with protein loops Biochemistry 38:11553-11559

Internal links
Protein Precursor Contryphan-R precursor (1310)
Nucleic acids
Structure THE CYCLIC PEPTIDE CONTRYPHAN-R FROM CONUS RADIATUS

External links
Ncbi 1QFB_A

Tools