PIIIE precursor (P01406) Protein Card

General Information
Name PIIIE precursor
Organism Conus purpurascens
Organism region Eastern Pacific
Organism diet piscivorous
Protein Type Precursor
Notes The ncbi and swiss-prot cards are presenting a sequence variant R74>G. The conoserver sequence corresponds to the sequence used for NMR studies.

Classification
Conopeptide class conotoxin
Gene superfamily M superfamily
Pharmacological family

Sequence
MSKLGALLTICLLLFPITA
LLMDGDQPADRPAERMDYDISS
EVHRLLERR
HPPCCMYGRCRRYPGCSSASCCQR
G
Sequence region
[1-19]signal sequence
[51-74]mature peptidePIIIE

References
Corpuz,G.P., Jacobsen,R.B., Jimenez,E.C., Watkins,M., Walker,C., Colledge,C., Garrett,J.E., McDougal,O., Li,W., Gray,W.R., Hillyard,D.R., Rivier,J., McIntosh,J.M., Cruz,L.J. and Olivera,B.M. (2005) Definition of the M-conotoxin superfamily: characterization of novel peptides from molluscivorous Conus venoms Biochemistry 44:8176-8186
Shon,K.J., Grilley,M., Jacobsen,R., Cartier,G.E., Hopkins,C., Gray,W.R., Watkins,M., Hillyard,D.R., Rivier,J., Torres,J., Yoshikami,D. and Olivera,B.M. (1997) A noncompetitive peptide inhibitor of the nicotinic acetylcholine receptor from Conus purpurascens venom Biochemistry 36:9581-9587
Mitchell,S.S., Shon,K.J., Foster,M.P., Davis,D.R., Olivera,B.M. and Ireland,C.M. (1998) Three-dimensional solution structure of conotoxin psi-PIIIE, an acetylcholine gated ion channel antagonist Biochemistry 37:1215-1220
Van Wagoner,R.M. and Ireland,C.M. (2003) An improved solution structure for psi-conotoxin PiiiE. Biochemistry 42:6347-6352

Internal links
Nucleic acids
Structure

External links
UniProtKB/Swiss-Prot P56529
Ncbi P56529

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