GIIIA precursor (P01464) Protein Card

General Information
Name GIIIA precursor
Alternative name(s) G16
Organism Conus geographus (Geography cone)
Organism region Indo-Pacific
Organism diet piscivorous
Protein Type Precursor
Notes Hu et al. 2012 determined a partial sequence.

Classification
Conopeptide class conotoxin
Gene superfamily M superfamily
Pharmacological family

Sequence
MSKLGVLLTICLLLFPLTA
LPMDGDEPANRPVERMQDNISS
EQYPLFEKR
RDCCTPPKKCKDRQCKPQRCCA
GR
Sequence region
[1-19]signal sequence
[51-72]mature peptideGIIIA

References
Corpuz,G.P., Jacobsen,R.B., Jimenez,E.C., Watkins,M., Walker,C., Colledge,C., Garrett,J.E., McDougal,O., Li,W., Gray,W.R., Hillyard,D.R., Rivier,J., McIntosh,J.M., Cruz,L.J. and Olivera,B.M. (2005) Definition of the M-conotoxin superfamily: characterization of novel peptides from molluscivorous Conus venoms Biochemistry 44:8176-8186
Cruz,L.J., Gray,W.R., Olivera,B.M., Zeikus,R.D., Kerr,L., Yoshikami,D. and Moczydlowski,E. (1985) Conus geographus toxins that discriminate between neuronal and muscle sodium channels J. Biol. Chem. 260:9280-9288
Sato,S., Nakamura,H., Ohizumi,Y., Kobayashi,J. and Hirata,Y. (1983) The amino acid sequences of homologous hydroxyproline-containing myotoxins from the marine snail Conus geographus venom FEBS Lett. 155:277-280
Hidaka,Y., Sato,K., Nakamura,H., Kobayashi,J., Ohizumi,Y. and Shimonishi,Y. (1990) Disulfide pairings in geographutoxin I, a peptide neurotoxin from Conus geographus FEBS Lett. 264:29-32
Ott,K.H., Becker,S., Gordon,R.D. and Ruterjans,H. (1991) Solution structure of mu-conotoxin GIIIA analysed by 2D-NMR and distance geometry calculations FEBS Lett. 278:160-166
Lancelin,J.M., Kohda,D., Tate,S., Yanagawa,Y., Abe,T., Satake,M. and Inagaki,F. (1991) Tertiary structure of conotoxin GIIIA in aqueous solution Biochemistry 30:6908-6916
Hu,H., Bandyopadhyay,P.K., Olivera,B.M. and Yandell,M. (2012) Elucidation of the molecular envenomation strategy of the cone snail Conus geographus through transcriptome sequencing of its venom duct. BMC Genomics 13:284

Internal links
Nucleic acids
Structure

External links
UniProtKB/Swiss-Prot P01523
Ncbi P01523

Tools