MVIIC (P01484) Protein Card

General Information
Name MVIIC
Alternative name(s) M7c,SNX-230
Organism Conus magus (Magus cone)
Organism region Indo-Pacific
Organism diet piscivorous
Protein Type Wild type
Protein precursor MVIIC precursor (822)

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework VI/VII
Pharmacological family omega conotoxin

Sequence
CKGKGAPCRKTMYDCCSGSCGRRGKC(nh2)
Modified residues
positionsymbolname
27nh2C-term amidation
Sequence evidence nucleic acid level
Average Mass 2749.24
Monoisotopic Mass 2747.16
Isoelectric Point 11.91
Extinction Coefficient [280nm] 1490.00

Activity

IC50: Voltage-Gated Calcium Channels

TargetOrganismIC50AgonistRef
Cav2.1R. norvegicus600pMMVIICLewis,R.J. et al. (2000)
Cav2.2R. norvegicus7.0nMGVIALewis,R.J. et al. (2000)

References
Hillyard,D.R., Monje,V.D., Mintz,I.M., Bean,B.P., Nadasdi,L., Ramachandran,J., Miljanich,G., Azimi-Zoonooz,A., McIntosh,J.M., Cruz,L.J. et al. (1992) A new Conus peptide ligand for mammalian presynaptic Ca2+ channels Neuron 9:69-77
Farr-Jones,S., Miljanich,G.P., Nadasdi,L., Ramachandran,J. and Basus,V.J. (1995) Solution structure of omega-conotoxin MVIIC, a high affinity ligand of P-type calcium channels, using 1H NMR spectroscopy and complete relaxation matrix analysis J. Mol. Biol. 248:106-124
Lewis,R.J., Nielsen,K.J., Craik,D.J., Loughnan,M.L., Adams,D.A., Sharpe,I.A., Luchian,T., Adams,D.J., Bond,T., Thomas,L., Jones,A., Matheson,J.L., Drinkwater,R., Andrews,P.R. and Alewood,P.F. (2000) Novel omega-conotoxins from Conus catus discriminate among neuronal calcium channel subtypes J. Biol. Chem. 275:35335-35344
Nielsen,K.J., Adams,D., Thomas,L., Bond,T., Alewood,P.F., Craik,D.J. and Lewis,R.J. (1999) Structure-activity relationships of omega-conotoxins MVIIA, MVIIC and 14 loop splice hybrids at N and P/Q-type calcium channels J. Mol. Biol. 289:1405-1421

Internal links
Protein Precursor MVIIC precursor (822)
Nucleic acids
Structure OMEGA-CONOTOXIN MVIIC FROM CONUS MAGUS
SOLUTION STRUCTURE OF OMEGA-CONOTOXIN MVIIC, A HIGH AFFINITY OF P-TYPE CALCIUM CHANNELS, USING 1H NMR SPECTROSCOPY AND COMPLETE RELAXATION MATRIX ANALYSIS

External links
Ncbi 1OMN_A, 1CNN_A

Tools