AnIB (P00015) Protein Card

General Information
Name AnIB
Alternative name(s) An1b
Organism Conus anemone
Organism region Indo-Pacific
Organism diet vermivorous
Protein Type Wild type

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework I
Pharmacological family alpha conotoxin

Sequence
GGCCSHPACAANNQD(sTy)C(nh2)
Modified residues
positionsymbolname
16sTySulfotyrosine
18nh2C-term amidation
Sequence evidence protein level
Average Mass 1787.87
Monoisotopic Mass 1786.51
Isoelectric Point 5.63
Extinction Coefficient [280nm] 1490.00

Activity

IC50: Nicotinic acetylcholine receptors

TargetOrganismIC50nhillAgonistRef
α3β2R. norvegicus280pM1.06100uM AchLoughnan,M.L. et al. (2004)
α7R. norvegicus76nM1.22100uM nicotineLoughnan,M.L. et al. (2004)

Synthetic variants
AnIB [Del1](nh2)C(sTy)DQNNAACAPHSCCG
AnIB [non amidated]C(sTy)DQNNAACAPHSCCGG
AnIB [sTy16Y](nh2)CYDQNNAACAPHSCCGG
Gly-AnIB(nh2)C(sTy)DQNNAACAPHSCCGGG

References
Loughnan,M.L., Nicke,A., Jones,A., Adams,D.J., Alewood,P.F. and Lewis,R.J. (2004) Chemical and functional identification and characterization of novel sulfated alpha-conotoxins from the cone snail Conus anemone J. Med. Chem. 47:1234-1241

Internal links
Nucleic acids
Structure

External links
UniProtKB/Swiss-Prot P0C1V7
Ncbi P0C1V7

Tools