CcTx (P01510) Protein Card

General Information
Name CcTx
Alternative name(s) Excitotoxin CcTx
Organism Conus consors
Organism region Indo-Pacific
Organism diet piscivorous
Protein Type Wild type
Protein precursor CcTx precursor (6154)
Notes Position 7 was recently identified (Violette et al. 2012) to be a glycosylated serine.

Classification
Conopeptide class conotoxin
Gene superfamily A superfamily
Cysteine framework IV
Pharmacological family

Sequence
AOWLVP(gSr)QITTCCGYNOGTMCOSCMCTNTC
Modified residues
positionsymbolname
2O4-Hydroxyproline
7gSrglycosylated serine
17O4-Hydroxyproline
22O4-Hydroxyproline
Sequence evidence protein level
Average Mass 3225.68
Monoisotopic Mass 3223.20
Isoelectric Point 8.09
Extinction Coefficient [280nm] 6990.00

References
Le Gall,F., Favreau,P., Benoit,E., Mattei,C., Bouet,F., Menou,J.L., Menez,A., Letourneux,Y. and Molgo,J. (1999) A new conotoxin isolated from Conus consors venom acting selectively on axons and motor nerve terminals through a Na+-dependent mechanism Eur. J. Neurosci. 11:3134-3142
Violette,A., Biass,D., Dutertre,S., Koua,D., Piquemal,D., Pierrat,F. and Favreau,P. (2012) Large-scale discovery of conopeptides and conoproteins in the injectable venom of a fish-hunting cone snail using a combined proteomic and transcriptomic approach. J Proteomics 75:5215-5225

Internal links
Protein Precursor CcTx precursor (6154)
Nucleic acids
Structure NMR structure of the glycosylated conotoxin CcTx from Conus consors

External links
UniProtKB/Swiss-Prot P58928
Ncbi P58928, 4B1Q_P

Tools