Gla-MrII (P01524) Protein Card

General Information
Name Gla-MrII
Alternative name(s) Mr019,Mr12.5
Organism Conus marmoreus
Organism region Indo-Pacific
Organism diet molluscivorous
Protein Type Wild type
Protein precursor Gla-MrII precursor (3859)
Gla-MrII precursor (5396)

Classification
Conopeptide class conotoxin
Gene superfamily I2 superfamily
Cysteine framework XII
Pharmacological family

Sequence
SCDS(Gla)FSS(Gla)FC(Gla)QP(Gla)(Gla)RICSC
STHVCCHLSSSKRDQCMTWNRCLSAQTGN
Modified residues
positionsymbolname
5GlaGamma carboxylic glutamic acid
9GlaGamma carboxylic glutamic acid
12GlaGamma carboxylic glutamic acid
15GlaGamma carboxylic glutamic acid
16GlaGamma carboxylic glutamic acid
Sequence evidence protein level
Average Mass 5864.18
Monoisotopic Mass 5860.16
Isoelectric Point 4.51
Extinction Coefficient [280nm] 5500.00

References
Hansson,K., Furie,B., Furie,B.C. and Stenflo,J. (2004) Isolation and characterization of three novel Gla-containing Conus marmoreus venom peptides, one with a novel cysteine pattern Biochem. Biophys. Res. Commun. 319:1081-1087
Dutertre,S., Jin,A.H., Kaas,Q., Jones,A., Alewood,P.F. and Lewis,R.J. (2013) Deep venomics reveals the mechanism for expanded peptide diversity in cone snail venom. Mol. Cell Proteomics 12:312-329

Internal links
Protein Precursor Gla-MrII precursor (3859)
Gla-MrII precursor (5396)
Nucleic acids
Structure

External links
UniProtKB/Swiss-Prot P69770
Ncbi P69770

Tools