CMrVIA (P01537) Protein Card

General Information
Name CMrVIA
Alternative name(s) Mr6a
Organism Conus marmoreus
Organism region Indo-Pacific
Organism diet molluscivorous
Protein Type Wild type

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework X
Pharmacological family chi conotoxin

Sequence
VCCGYKLCHOC
Modified residues
positionsymbolname
10O4-Hydroxyproline
Sequence evidence protein level
Average Mass 1237.48
Monoisotopic Mass 1236.45
Isoelectric Point 9.67
Extinction Coefficient [280nm] 1490.00

Synthetic variants
CMrVIA [K6P]COHCLPYGCCV
CMrVIA [K6P] amidated(nh2)COHCLPYGCCV
CMrVIA amidated(nh2)COHCLKYGCCV

References
Kang,T.S., Jois,S.D. and Kini,R.M. (2006) Solution structures of two structural isoforms of CMrVIA chi/lambda-conotoxin Biomacromolecules 7:2337-2346
Balaji,R.A., Ohtake,A., Sato,K., Gopalakrishnakone,P., Kini,R.M., Seow,K.T. and Bay,B.H. (2000) lambda-conotoxins, a new family of conotoxins with unique disulfide pattern and protein folding. Isolation and characterization from the venom of Conus marmoreus J. Biol. Chem. 275:39516-39522

Internal links
Nucleic acids
Structure SOLUTION STRUCTURE OF RIBBON ISOFORM OF CMRVIA LAMBDA CONOTOXIN
SOLUTION STRUCTURE OF GLOBULAR CONFORMATION OF CMRVIA LAMBDA CONOTOXIN

External links
Ncbi 2B5Q_A, 2B5P_A, P58807

Tools