TxVA (P01543) Protein Card

General Information
Name TxVA
Alternative name(s) Tx-012,TxIX,tx5a
Organism Conus textile (Cloth-of-gold cone)
Organism region Indo-Pacific
Organism diet molluscivorous
Protein Type Wild type
Protein precursor TxVA precursor (645)
TxVA precursor (649)
TxVA precursor (2959)

Classification
Conopeptide class conotoxin
Gene superfamily T superfamily
Cysteine framework V
Pharmacological family epsilon conotoxin

Sequence
(Gla)CC(Gla)DG(BTr)CC(gTr)AAO
Modified residues
positionsymbolname
1GlaGamma carboxylic glutamic acid
4GlaGamma carboxylic glutamic acid
7BTrBromotryptophan
10gTrglycosylated threonine
13O4-Hydroxyproline
Sequence evidence protein level
Average Mass 1931.74
Monoisotopic Mass 1929.42
Isoelectric Point 1.83
Extinction Coefficient [280nm] NA

References
Kalume,D.E., Stenflo,J., Czerwiec,E., Hambe,B., Furie,B.C., Furie,B. and Roepstorff,P. (2000) Structure determination of two conotoxins from Conus textile by a combination of matrix-assisted laser desorption/ionization time-of-flight and electrospray ionization mass spectrometry and biochemical methods J Mass Spectrom 35:145-156
Walker,C.S., Steel,D., Jacobsen,R.B., Lirazan,M.B., Cruz,L.J., Hooper,D., Shetty,R., DelaCruz,R.C., Nielsen,J.S., Zhou,L.M., Bandyopadhyay,P., Craig,A.G. and Olivera,B.M. (1999) The T-superfamily of conotoxins J. Biol. Chem. 274:30664-30671
Rigby,A.C., Lucas-Meunier,E., Kalume,D.E., Czerwiec,E., Hambe,B., Dahlqvist,I., Fossier,P., Baux,G., Roepstorff,P., Baleja,J.D., Furie,B.C., Furie,B. and Stenflo,J. (1999) A conotoxin from Conus textile with unusual posttranslational modifications reduces presynaptic Ca2+ influx Proc. Natl. Acad. Sci. U.S.A. 96:5758-5763

Internal links
Protein Precursor TxVA precursor (645)
TxVA precursor (649)
TxVA precursor (2959)
Nucleic acids
Structure A NOVEL CONOTOXIN FROM CONUS TEXTILE WITH UNUSUAL POST-TRANSLATIONAL MODIFICATIONS REDUCES PRESYNAPTIC CALCIUM INFLUX, NMR, 1 STRUCTURE, GLYCOSYLATED PROTEIN

External links
Ncbi 1WCT, 1WCT_A

Tools