TxVIA (P01552) Protein Card

General Information
Name TxVIA
Alternative name(s) KK-0,King-Kong 0,Tx6a,TxIA
Organism Conus textile (Cloth-of-gold cone)
Organism region Indo-Pacific
Organism diet molluscivorous
Protein Type Wild type
Protein precursor TxVIA precursor (598)
TxVIA precursor (1094)
TxVIA precursor (3025)
TxVIA precursor (3026)
Notes TxVIA makes lobsters assume dominant posture; contraction in snails; no symptom in mice. It was also recently reported to have insecticidal activity, including for the cabbage moth and house fly (Bruce et al. 2011). It has no effect on grey field slug Deroceras reticulatum (Bruce et al. 2011). The methionine was found to be oxidated by Dobson 2012.

Classification
Conopeptide class conotoxin
Gene superfamily O1 superfamily
Cysteine framework VI/VII
Pharmacological family delta conotoxin

Sequence
WCKQSGEMCNLLDQNCCDGYCIVLVCT
Sequence evidence protein level
Average Mass 3036.49
Monoisotopic Mass 3034.19
Isoelectric Point 4.79
Extinction Coefficient [280nm] 6990.00

References
Hillyard,D.R., Olivera,B.M., Woodward,S., Corpuz,G.P., Gray,W.R., Ramilo,C.A. and Cruz,L.J. (1989) A molluscivorous Conus toxin: conserved frameworks in conotoxins Biochemistry 28:358-361
Fainzilber,M., Gordon,D., Hasson,A., Spira,M.E. and Zlotkin,E. (1991) Mollusc-specific toxins from the venom of Conus textile neovicarius Eur. J. Biochem. 202:589-595
Kohno,T., Sasaki,T., Kobayashi,K., Fainzilber,M. and Sato,K. (2002) Three-dimensional solution structure of the sodium channel agonist/antagonist delta-conotoxin TxVIA J. Biol. Chem. 277:36387-36391
Ueberheide,B.M., Fenyƶ,D., Alewood,P.F. and Chait,B.T. (2009) Rapid sensitive analysis of cysteine rich peptide venom components. Proc. Natl. Acad. Sci. U.S.A. 106:6910-6915
Bruce,C., Fitches,E.C., Chougule,N., Bell,H.A. and Gatehouse,J.A. (2011) Recombinant conotoxin, TxVIA, produced in yeast has insecticidal activity. Toxicon 58:93-100
Bhatia,S., Kil,Y.J., Ueberheide,B., Chait,B.T., Tayo,L., Cruz,L., Lu,B., Yates,J.R. 3rd. and Bern,M. (2012) Constrained de novo sequencing of conotoxins. J. Proteome Res. 11:4191-4200
Dobson,R., Collodoro,M., Gilles,N., Turtoi,A., De Pauw,E. and Quinton,L. (2012) Secretion and maturation of conotoxins in the venom ducts of Conus textile. Toxicon 60:1370-1379

Internal links
Protein Precursor TxVIA precursor (598)
TxVIA precursor (1094)
TxVIA precursor (3025)
TxVIA precursor (3026)
Nucleic acids
Structure THREE-DIMENSIONAL STRUCTURE IN SOLUTION OF THE SODIUM CHANNEL AGONIST/ANTAGONIST DELTA-CONOTOXIN TXVIA

External links
Ncbi 1FU3_A, AAB20785

Tools