CnIA (P01558) Protein Card

General Information
Name CnIA
Alternative name(s) Cn1a
Organism Conus consors
Organism region Indo-Pacific
Organism diet piscivorous
Protein Type Wild type
Protein precursor CnIA/B/L precursor (5244)
CnIA/B/K precursor (5532)

Classification
Conopeptide class conotoxin
Gene superfamily A superfamily
Cysteine framework I
Pharmacological family alpha conotoxin

Sequence
GRCCHPACGKYYSC(nh2)
Modified residues
positionsymbolname
15nh2C-term amidation
Sequence evidence protein level
Average Mass 1542.78
Monoisotopic Mass 1541.58
Isoelectric Point 11.81
Extinction Coefficient [280nm] 2980.00

Activity

IC50: Nicotinic acetylcholine receptors

TargetOrganismIC50AgonistRef
α1β1γδT. marmorata190nM2nM [125I]-R-BgtxFavreau,P. et al. (1999)
α7-5HT3 chimaeraG. gallus14.8uM100nM [125I]-R-BgtxFavreau,P. et al. (1999)

References
Favreau,P., Krimm,I., le Gall,F., Bobenrieth,M.J., Lamthanh,H., Bouet,F., Servent,D., Molgo,J., Menez,A., Letourneux,Y. and Lancelin,J.-M. (1999) Biochemical characterization and nuclear magnetic resonance structure of novel alpha-conotoxins isolated from the venom of Conus consors Biochemistry 38:6317-6326
Violette,A., Biass,D., Dutertre,S., Koua,D., Piquemal,D., Pierrat,F. and Favreau,P. (2012) Large-scale discovery of conopeptides and conoproteins in the injectable venom of a fish-hunting cone snail using a combined proteomic and transcriptomic approach. J Proteomics 75:5215-5225

Internal links
Protein Precursor CnIA/B/L precursor (5244)
CnIA/B/K precursor (5532)
Nucleic acids
Structure ALPHA-CNIA CONOTOXIN FROM CONUS CONSORS, NMR, 43 STRUCTURES

External links
UniProtKB/Swiss-Prot P56973
Ncbi 1B45_A

Tools