EVIA (P01561) Protein Card

General Information
Name EVIA
Alternative name(s) E6a
Organism Conus ermineus (Atlantic fish-hunting cone)
Organism region Eastern Atlantic and Mediterranean,Western Atlantic and Caribbean
Organism diet piscivorous
Protein Type Wild type

Classification
Conopeptide class conotoxin
Gene superfamily O1 superfamily
Cysteine framework VI/VII
Pharmacological family delta conotoxin

Sequence
DDCIKOYGFCSLPILKNGLCCSGACVGVCADL(nh2)
Modified residues
positionsymbolname
6O4-Hydroxyproline
33nh2C-term amidation
Sequence evidence protein level
Average Mass 3287.85
Monoisotopic Mass 3285.44
Isoelectric Point 5.71
Extinction Coefficient [280nm] 1490.00

References
Volpon,L., Lamthanh,H., Barbier,J., Gilles,N., Molgo,J., Menez,A. and Lancelin,J.M. (2004) NMR solution structures of delta-conotoxin EVIA from Conus ermineus that selectively acts on vertebrate neuronal Na+ channels J. Biol. Chem. 279:21356-21366
Barbier,J., Lamthanh,H., Le Gall,F., Favreau,P., Benoit,E., Chen,H., Gilles,N., Ilan,N., Heinemann,S.H., Gordon,D., Menez,A. and Molgo,J. (2004) A delta-conotoxin from Conus ermineus venom inhibits inactivation in vertebrate neuronal Na+ channels but not in skeletal and cardiac muscles J. Biol. Chem. 279:4680-4685

Internal links
Nucleic acids
Structure NMR SOLUTION STRUCTURES OF DELTA-CONOTOXIN EVIA FROM CONUS ERMINEUS THAT SELECTIVELY ACTS ON VERTEBRATE NEURONAL NA+ CHANNELS
NMR SOLUTION STRUCTURES OF DELTA-CONOTOXIN EVIA FROM CONUS ERMINEUS THAT SELECTIVELY ACTS ON VERTEBRATE NEURONAL NA+ CHANNELS, LEU12-PRO13 CIS ISOMER

External links
UniProtKB/Swiss-Prot P60513
Ncbi 1G1Z_A, 1G1P_A, P60513

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