EVIA (P01561) Protein Card

General Information
Name EVIA
Alternative name(s) E6a
Organism Conus ermineus (Atlantic fish-hunting cone)
Organism region Eastern Atlantic and Mediterranean,Western Atlantic and Caribbean
Organism diet piscivorous
Protein Type Wild type
Protein precursor EVIA precursor (8467)

Classification
Conopeptide class conotoxin
Gene superfamily O1 superfamily
Cysteine framework VI/VII
Pharmacological family delta conotoxin

Sequence
DDCIKOYGFCSLPILKNGLCCSGACVGVCADL(nh2)
Modified residues
positionsymbolname
6O4-Hydroxyproline
33nh2C-term amidation
Sequence evidence protein level
Average Mass 3287.85
Monoisotopic Mass 3285.44
Isoelectric Point 5.71
Extinction Coefficient [280nm] 1490.00

References
Volpon,L., Lamthanh,H., Barbier,J., Gilles,N., Molgo,J., Menez,A. and Lancelin,J.M. (2004) NMR solution structures of delta-conotoxin EVIA from Conus ermineus that selectively acts on vertebrate neuronal Na+ channels J. Biol. Chem. 279:21356-21366
Barbier,J., Lamthanh,H., Le Gall,F., Favreau,P., Benoit,E., Chen,H., Gilles,N., Ilan,N., Heinemann,S.H., Gordon,D., Menez,A. and Molgo,J. (2004) A delta-conotoxin from Conus ermineus venom inhibits inactivation in vertebrate neuronal Na+ channels but not in skeletal and cardiac muscles J. Biol. Chem. 279:4680-4685

Internal links
Protein Precursor EVIA precursor (8467)
Nucleic acids
Structure NMR SOLUTION STRUCTURES OF DELTA-CONOTOXIN EVIA FROM CONUS ERMINEUS THAT SELECTIVELY ACTS ON VERTEBRATE NEURONAL NA+ CHANNELS
NMR SOLUTION STRUCTURES OF DELTA-CONOTOXIN EVIA FROM CONUS ERMINEUS THAT SELECTIVELY ACTS ON VERTEBRATE NEURONAL NA+ CHANNELS, LEU12-PRO13 CIS ISOMER

External links
UniProtKB/Swiss-Prot P60513
Ncbi 1G1Z_A, 1G1P_A, P60513

Tools