GIIIA [R13A] (P01570) Protein Card

General Information
Name GIIIA [R13A]
Organism synthetic construct
Protein Type Synthetic
Parent GIIIA
Notes Inactive Analog

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework III
Pharmacological family mu conotoxin

Sequence
RDCCTOOKKCKDAQCKOQRCCA(nh2)
Modified residues
positionsymbolname
6O4-Hydroxyproline
7O4-Hydroxyproline
17O4-Hydroxyproline
23nh2C-term amidation
Average Mass 2523.93
Monoisotopic Mass 2522.05
Isoelectric Point 11.48
Extinction Coefficient [280nm] NA

References
Lancelin,J.M., Kohda,D., Tate,S., Yanagawa,Y., Abe,T., Satake,M. and Inagaki,F. (1991) Tertiary structure of conotoxin GIIIA in aqueous solution Biochemistry 30:6908-6916
Wakamatsu,K., Kohda,D., Hatanaka,H., Lancelin,J.M., Ishida,Y., Oya,M., Nakamura,H., Inagaki,F. and Sato,K. (1992) Structure-activity relationships of mu-conotoxin GIIIA: structure determination of active and inactive sodium channel blocker peptides by NMR and simulated annealing calculations Biochemistry 31:12577-12584

Internal links
Nucleic acids
Structure STRUCTURE-ACTIVITY RELATIONSHIPS OF MU-CONOTOXIN GIIIA: STRUCTURE DETERMINATION OF ACTIVE AND INACTIVE SODIUM CHANNEL BLOCKER PEPTIDES BY NMR AND SIMULATED ANNEALING CALCULATIONS
STRUCTURE-ACTIVITY RELATIONSHIPS OF MU-CONOTOXIN GIIIA: STRUCTURE DETERMINATION OF ACTIVE AND INACTIVE SODIUM CHANNEL BLOCKER PEPTIDES BY NMR AND SIMULATED ANNEALING CALCULATIONS

External links
UniProtKB/Swiss-Prot P01523
Ncbi 1TCK_A, 1TCH_A

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