CnVIIA (P01632) Protein Card

General Information
Name CnVIIA
Alternative name(s) Cn7a,CnVIIH
Organism Conus consors
Organism region Indo-Pacific
Organism diet piscivorous
Protein Type Wild type
Protein precursor CnVIIA precursor (6156)
Notes CnVIIH corresponds to CnVIIA with an unprocessed final glycine, and therefore no C-terminal amidation (Violette et al. 2012).

Classification
Conopeptide class conotoxin
Gene superfamily O1 superfamily
Cysteine framework VI/VII
Pharmacological family omega conotoxin

Sequence
CKGKGAOCTRL(Mox)YDCCHGSCSSSKGRC(nh2)
Modified residues
positionsymbolname
7O4-Hydroxyproline
12MoxOxomethionine
28nh2C-term amidation
Sequence evidence protein level
Average Mass 2832.22
Monoisotopic Mass 2830.16
Isoelectric Point 11.95
Extinction Coefficient [280nm] 1490.00

Activity

IC50: Voltage-Gated Calcium Channels

TargetOrganismIC50AgonistRef
Cav2.1R. norvegicus179nMMVIICFavreau,P. et al. (2001)
Cav2.2R. norvegicus2.7-3.7pMGVIAFavreau,P. et al. (2001)
1.13pMCNVIIAFavreau,P. et al. (2001)

References
Favreau,P., Gilles,N., Lamthanh,H., Bournaud,R., Shimahara,T., Bouet,F., Laboute,P., Letourneux,Y., Menez,A., Molgo,J. and Le Gall,F. (2001) A new omega-conotoxin that targets N-type voltage-sensitive calcium channels with unusual specificity Biochemistry 40:14567-14575
Violette,A., Biass,D., Dutertre,S., Koua,D., Piquemal,D., Pierrat,F. and Favreau,P. (2012) Large-scale discovery of conopeptides and conoproteins in the injectable venom of a fish-hunting cone snail using a combined proteomic and transcriptomic approach. J Proteomics 75:5215-5225

Internal links
Protein Precursor CnVIIA precursor (6156)
Nucleic acids
Structure

External links
UniProtKB/Swiss-Prot P58916
Ncbi P58916

Tools