MVIIB (P01638) Protein Card

General Information
Name MVIIB
Alternative name(s) SNX-159
Organism Conus magus (Magus cone)
Organism region Indo-Pacific
Organism diet piscivorous
Protein Type Wild type

Classification
Conopeptide class conotoxin
Gene superfamily O1 superfamily
Cysteine framework VI/VII
Pharmacological family omega conotoxin

Sequence
CKGKGASCHRTSYDCCTGSCNRGKC(nh2)
Modified residues
positionsymbolname
26nh2C-term amidation
Sequence evidence protein level
Average Mass 2618.94
Monoisotopic Mass 2617.03
Isoelectric Point 11.95
Extinction Coefficient [280nm] 1490.00

Activity

IC50: Voltage-Gated Calcium Channels

TargetOrganismIC50AgonistRef
Cav2.2R. norvegicus101pMMVIIAMiljanich,G.P. et al. (1993)

References
Olivera,B.M., Cruz,L.J., de Santos,V., Lecheminant,G.W., Griffin,D., Zeikus,R.D., McIntosh,J.M., Galyean,R., Varga,J., Gray,W.R. and Rivier,J.E. (1987) Neuronal calcium channel antagonists. Discrimination between calcium channel subtypes using omega-conotoxin from Conus magus venom Biochemistry 26:2086-2090
Miljanich,G.P., Bowersox,S.S., Fox,J.A., Valentino,K.L., Bitner,R.S. and Yamashiro,D.H. (1993) Compositions for Delayed Treatment of Ischemia-related Neuronal Damage. Patent: PCT/US92 09766; Classification, C07K 7/10, A61K 37/02.
Kapono,C.A., Thapa,P., Cabalteja,C.C., Guendisch,D., Collier,A.C. and Bingham,J.P. (2013) Conotoxin truncation as a post-translational modification to increase the pharmacological diversity within the milked venom of Conus magus. Toxicon

Internal links
Nucleic acids
Structure

External links
UniProtKB/Swiss-Prot P05485
Ncbi P05485

Tools