MVIIA[R10K] (P01661) Protein Card

General Information
Name MVIIA[R10K]
Organism synthetic construct
Protein Type Synthetic
Parent MVIIA

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework VI/VII
Pharmacological family omega conotoxin

Sequence
CKGKGAKCSKLMYDCCTGSCRSGKC(nh2)
Modified residues
positionsymbolname
26nh2C-term amidation
Average Mass 2611.10
Monoisotopic Mass 2609.09
Isoelectric Point 11.69
Extinction Coefficient [280nm] 1490.00

Activity

IC50: Voltage-Gated Calcium Channels

TargetOrganismIC50AgonistRef
Cav2.2R. norvegicus25pMGVIAMould,J. et al. (2004)

References
Adams,D.J., Smith,A.B., Schroeder,C.I., Yasuda,T. and Lewis,R.J. (2003) Omega-conotoxin CVID inhibits a pharmacologically distinct voltage-sensitive calcium channel associated with transmitter release from preganglionic nerve terminals J. Biol. Chem. 278:4057-4062
Mould,J., Yasuda,T., Schroeder,C.I., Beedle,A.M., Doering,C.J., Zamponi,G.W., Adams,D.J. and Lewis,R.J. (2004) The alpha2delta auxiliary subunit reduces affinity of omega-conotoxins for recombinant N-type (Cav2.2) calcium channels. J. Biol. Chem. 279:34705-34714

Internal links
Nucleic acids
Structure NMR SOULUTION STRUCTURE OF OMEGA-CONOTOXIN [K10]MVIIA

External links
Ncbi 1TT3_A

Tools