CnIIIB (P01690) Protein Card

General Information
Name CnIIIB
Alternative name(s) Cn3b
Organism Conus consors
Organism region Indo-Pacific
Organism diet piscivorous
Protein Type Wild type
Notes Block tetrodotoxin resistant (TTX-R) Na channels and the blockade is irreversible (zhang et al 2006)

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework III
Pharmacological family mu conotoxin

Sequence
ZGCCGEPNLCFTRWCRNNARCCRQQ
Modified residues
positionsymbolname
1ZPyroglutamic acid
Sequence evidence protein level
Average Mass 2924.28
Monoisotopic Mass 2922.15
Isoelectric Point NA
Extinction Coefficient [280nm] NA

Activity

Percentage inhibition: Voltage-Gated Sodium Channels

TargetOrganism% inhibitionConcentrationRef
Nav TTX-RR. pipiens25+/-45uMZhang,M.M. et al. (2006)

References
Zhang,M.M., Fiedler,B., Green,B.R., Catlin,P., Watkins,M., Garrett,J.E., Smith,B.J., Yoshikami,D., Olivera,B.M. and Bulaj,G. (2006) Structural and functional diversities among mu-conotoxins targeting TTX-resistant sodium channels Biochemistry 45:3723-3732
Violette,A., Biass,D., Dutertre,S., Koua,D., Piquemal,D., Pierrat,F. and Favreau,P. (2012) Large-scale discovery of conopeptides and conoproteins in the injectable venom of a fish-hunting cone snail using a combined proteomic and transcriptomic approach. J Proteomics 75:5215-5225

Internal links
Nucleic acids
Structure

External links
UniProtKB/Swiss-Prot P0C1U0
Ncbi P0C1U0

Tools