CIIIA (P01692) Protein Card

General Information
Name CIIIA
Alternative name(s) C3a
Organism Conus catus
Organism region Indo-Pacific
Organism diet piscivorous
Protein Type Wild type
Notes Block tetrodotoxin resistant (TTX-R) Na channels and the blockade is slow and reversible (Zhang et al 2006).

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework III
Pharmacological family mu conotoxin

Sequence
GRCCEGPNGCSSRWCKDHARCC(nh2)
Modified residues
positionsymbolname
23nh2C-term amidation
Sequence evidence protein level
Average Mass 2421.71
Monoisotopic Mass 2419.90
Isoelectric Point 11.53
Extinction Coefficient [280nm] 5500.00

Activity

Percentage inhibition: Voltage-Gated Sodium Channels

TargetOrganism% inhibitionConcentrationRef
Nav TTX-RR. pipiens96+/-45uMZhang,M.M. et al. (2006)

References
Zhang,M.M., Fiedler,B., Green,B.R., Catlin,P., Watkins,M., Garrett,J.E., Smith,B.J., Yoshikami,D., Olivera,B.M. and Bulaj,G. (2006) Structural and functional diversities among mu-conotoxins targeting TTX-resistant sodium channels Biochemistry 45:3723-3732

Internal links
Nucleic acids
Structure

External links
UniProtKB/Swiss-Prot P0C1U1
Ncbi P0C1U1

Tools