CVIB (P01726) Protein Card

General Information
Name CVIB
Alternative name(s) C6b
Organism Conus catus
Organism region Indo-Pacific
Organism diet piscivorous
Protein Type Wild type
Notes The superfamily assignment is based on the close homology with CVIA.

Classification
Conopeptide class conotoxin
Gene superfamily O1 superfamily
Cysteine framework VI/VII
Pharmacological family omega conotoxin

Sequence
CKGKGASCRKTMYDCCRGSCRSGRC(nh2)
Modified residues
positionsymbolname
26nh2C-term amidation
Sequence evidence protein level
Average Mass 2710.16
Monoisotopic Mass 2708.12
Isoelectric Point 12.17
Extinction Coefficient [280nm] 1490.00

Activity

IC50: Voltage-Gated Calcium Channels

TargetOrganismIC50nhillAgonistRef
Cav2.1R. norvegicus11nMMVIICLewis,R.J. et al. (2000)
Cav2.2R. norvegicus7.7nMGVIALewis,R.J. et al. (2000)
12.0nM+/-2.30.47Berecki,G. et al. (2010)

References
Lewis,R.J., Nielsen,K.J., Craik,D.J., Loughnan,M.L., Adams,D.A., Sharpe,I.A., Luchian,T., Adams,D.J., Bond,T., Thomas,L., Jones,A., Matheson,J.L., Drinkwater,R., Andrews,P.R. and Alewood,P.F. (2000) Novel omega-conotoxins from Conus catus discriminate among neuronal calcium channel subtypes J. Biol. Chem. 275:35335-35344

Internal links
Nucleic acids
Structure

External links
UniProtKB/Swiss-Prot P58918
Ncbi P58918

Tools