TVIA (P01727) Protein Card

General Information
Name TVIA
Alternative name(s) SNX-185
Organism Conus tulipa (tulip cone)
Organism region Indo-Pacific
Organism diet piscivorous
Protein Type Wild type

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework VI/VII
Pharmacological family omega conotoxin

Sequence
CLSOGSSCSOTSYNCCRSCNOYSRKC
Modified residues
positionsymbolname
4O4-Hydroxyproline
10O4-Hydroxyproline
21O4-Hydroxyproline
Sequence evidence Unknown
Average Mass 2846.11
Monoisotopic Mass 2844.05
Isoelectric Point 11.01
Extinction Coefficient [280nm] 2980.00

Activity

IC50: Voltage-Gated Calcium Channels

TargetOrganismIC50AgonistRef
Cav2.2R. norvegicus228pMMVIIAMiljanich,G.P. et al. (1993)

References
Chung,D., Gaur,S., Bell,J.R., Ramachandran,J. and Nadasdi,L. (1995) Determination of disulfide bridge pattern in omega-conopeptides Int. J. Pept. Protein Res. 46:320-325
Miljanich,G.P., Bitner,R.S., Bowersox,S.S., Fox,J.A., Valentino,K.L. and Yamashiro,D.H. (1991) Patent: 5051403, -US 24-SEP-1991;
Miljanich,G.P. and Ramachandran,J. (1995) Antagonists of neuronal calcium channels: structure, function, and therapeutic implications Annu. Rev. Pharmacol. Toxicol. 35:707

Internal links
Nucleic acids
Structure

External links
UniProtKB/Swiss-Prot P58915
Ncbi P58915

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