MrIA precursor (P01739) Protein Card

General Information
Name MrIA precursor
Alternative name(s) Mr090
Organism Conus marmoreus
Organism region Indo-Pacific
Organism diet molluscivorous
Protein Type Precursor

Classification
Conopeptide class conotoxin
Gene superfamily T superfamily
Pharmacological family

Sequence
MRCLPVLIILLLLTASAPG
VVVLPKTEDDVPMSSVYGNGKS
ILRGILR
NGVCCGYKLCHPC
Sequence region
[1-19]signal sequence
[49-61]mature peptideMrIA

References
Balaji,R.A., Ohtake,A., Sato,K., Gopalakrishnakone,P., Kini,R.M., Seow,K.T. and Bay,B.H. (2000) lambda-conotoxins, a new family of conotoxins with unique disulfide pattern and protein folding. Isolation and characterization from the venom of Conus marmoreus J. Biol. Chem. 275:39516-39522
Sharpe,I.A., Gehrmann,J., Loughnan,M.L., Thomas,L., Adams,D.A., Atkins,A., Palant,E., Craik,D.J., Adams,D.J., Alewood,P.F. and Lewis,R.J. (2001) Two new classes of conopeptides inhibit the alpha1-adrenoceptor and noradrenaline transporter Nat. Neurosci. 4:902-907
McIntosh,J.M., Corpuz,G.O., Layer,R.T., Garrett,J.E., Wagstaff,J.D., Bulaj,G., Vyazovkina,A., Yoshikami,D., Cruz,L.J. and Olivera,B.M. (2000) Isolation and characterization of a novel conus peptide with apparent antinociceptive activity J. Biol. Chem. 275:32391-32397
Sharpe,I.A., Palant,E., Schroeder,C.I., Kaye,D.M., Adams,D.J., Alewood,P.F. and Lewis,R.J. (2003) Inhibition of the norepinephrine transporter by the venom peptide chi-MrIA. Site of action, Na+ dependence, and structure-activity relationship J. Biol. Chem. 278:40317-40323
Bryan-Lluka,L.J., Bonisch,H. and Lewis,R.J. (2003) chi-Conopeptide MrIA partially overlaps desipramine and cocaine binding sites on the human norepinephrine transporter J. Biol. Chem. 278:40324-40329
Nielsen,C.K., Lewis,R.J., Alewood,D., Drinkwater,R., Palant,E., Patterson,M., Yaksh,T.L., McCumber,D. and Smith,M.T. (2005) Anti-allodynic efficacy of the chi-conopeptide, Xen2174, in rats with neuropathic pain Pain 118:112-124
Nilsson,K.P., Lovelace,E.S., Caesar,C.E., Tynngard,N., Alewood,P.F., Johansson,H.M., Sharpe,I.A., Lewis,R.J., Daly,N.L. and Craik,D.J. (2005) Solution structure of chi-conopeptide MrIA, a modulator of the human norepinephrine transporter Biopolymers 80:815-823
Dutertre,S., Jin,A.H., Kaas,Q., Jones,A., Alewood,P.F. and Lewis,R.J. (2013) Deep venomics reveals the mechanism for expanded peptide diversity in cone snail venom. Mol. Cell Proteomics 12:312-329

Internal links
Nucleic acids Conus marmoreus conotoxin 10a gene, partial cds.
Structure

External links
UniProtKB/Swiss-Prot P58808
Ncbi ADN79126, ADB93082, P58808

Tools