EIVB (P01740) Protein Card

General Information
Name EIVB
Alternative name(s) E4b
Organism Conus ermineus (Atlantic fish-hunting cone)
Organism region Eastern Atlantic and Mediterranean,Western Atlantic and Caribbean
Organism diet piscivorous
Protein Type Wild type

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework IV
Pharmacological family alpha conotoxin

Sequence
GCCGKYONAACHOCGCTVGROOYCDROSGG(nh2)
Modified residues
positionsymbolname
7O4-Hydroxyproline
13O4-Hydroxyproline
21O4-Hydroxyproline
22O4-Hydroxyproline
27O4-Hydroxyproline
31nh2C-term amidation
Sequence evidence protein level
Average Mass 3100.40
Monoisotopic Mass 3098.18
Isoelectric Point 10.05
Extinction Coefficient [280nm] 2980.00

Activity

IC50: Nicotinic acetylcholine receptors

TargetOrganismIC50AgonistRef
α1β1γδT. marmorata18nM10uM AchJacobsen,R.B. et al. (1997)

References
Jacobsen,R.B., Yoshikami,D., Ellison,M., Martinez,J., Gray,W.R., Cartier,G.E., Shon,K.-J., Groebe,D.R., Abramson,S.N., Olivera,B.M. and McIntosh,J.M. (1997) Differential targeting of nicotinic acetylcholine receptors by novel alphaA-conotoxins J. Biol. Chem. 272:22531-22537

Internal links
Nucleic acids
Structure

External links
UniProtKB/Swiss-Prot P58783
Ncbi P58783

Tools