GVIIA (P01743) Protein Card

General Information
Name GVIIA
Alternative name(s) SNX-178
Organism Conus geographus (Geography cone)
Organism region Indo-Pacific
Organism diet piscivorous
Protein Type Wild type
Protein precursor GVIIA precursor (5754)

Classification
Conopeptide class conotoxin
Gene superfamily O1 superfamily
Cysteine framework VI/VII
Pharmacological family omega conotoxin

Sequence
CKSOGTOCSRGMRDCCTSCLLYSNKCRRY
Modified residues
positionsymbolname
4O4-Hydroxyproline
7O4-Hydroxyproline
Sequence evidence protein level
Average Mass 3315.80
Monoisotopic Mass 3313.38
Isoelectric Point 11.70
Extinction Coefficient [280nm] 2980.00

Activity

IC50: Voltage-Gated Calcium Channels

TargetOrganismIC50AgonistRef
Cav2.2R. norvegicus3.70nMMVIIAMiljanich,G.P. et al. (1993)

References
Olivera,B.M., Gray,W.R., Zeikus,R., McIntosh,J.M., Varga,J., Rivier,J., de Santos,V. and Cruz,L.J. (1985) Peptide neurotoxins from fish-hunting cone snails Science 230:1338-1343

Internal links
Protein Precursor GVIIA precursor (5754)
Nucleic acids
Structure

External links
UniProtKB/Swiss-Prot P05483
Ncbi P05483

Tools