GIIIC (P01744) Protein Card

General Information
Name GIIIC
Alternative name(s) G3c
Organism Conus geographus (Geography cone)
Organism region Indo-Pacific
Organism diet piscivorous
Protein Type Wild type
Notes Bind to tetrodotoxin sensitive Na channel (Cruz et al 1985) and, presumably, interact with site 1 in the Na channel pore.

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework III
Pharmacological family mu conotoxin

Sequence
RDCCTOOKKCKDRRCKOLKCCA(nh2)
Modified residues
positionsymbolname
6O4-Hydroxyproline
7O4-Hydroxyproline
17O4-Hydroxyproline
23nh2C-term amidation
Sequence evidence protein level
Average Mass 2594.11
Monoisotopic Mass 2592.18
Isoelectric Point 11.94
Extinction Coefficient [280nm] NA

References
Cruz,L.J., Gray,W.R., Olivera,B.M., Zeikus,R.D., Kerr,L., Yoshikami,D. and Moczydlowski,E. (1985) Conus geographus toxins that discriminate between neuronal and muscle sodium channels J. Biol. Chem. 260:9280-9288

Internal links
Nucleic acids
Structure

External links
UniProtKB/Swiss-Prot P05482
Ncbi P05482

Tools