GVIA [O10>K] (P01780) Protein Card

General Information
Name GVIA [O10>K]
Organism synthetic construct
Protein Type Synthetic
Parent GVIA

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework VI/VII
Pharmacological family omega conotoxin

Sequence
CKSOGSSCSKTSYNCCRSCNOYTKRCY(nh2)
Modified residues
positionsymbolname
4O4-Hydroxyproline
21O4-Hydroxyproline
28nh2C-term amidation
Average Mass 3052.40
Monoisotopic Mass 3050.20
Isoelectric Point 11.06
Extinction Coefficient [280nm] 4470.00

Activity

IC50: Voltage-Gated Calcium Channels

TargetOrganismIC50AgonistRef
Cav2.2R. norvegicus19pMGVIAMould,J. et al. (2004)

References
Mould,J., Yasuda,T., Schroeder,C.I., Beedle,A.M., Doering,C.J., Zamponi,G.W., Adams,D.J. and Lewis,R.J. (2004) The alpha2delta auxiliary subunit reduces affinity of omega-conotoxins for recombinant N-type (Cav2.2) calcium channels J. Biol. Chem. 279:34705-34714

Internal links
Nucleic acids
Structure NMR SOLUTION STRUCTURE OF OMEGA-CONOTOXIN [K10]GVIA, A CYCLIC CYSTEINE KNOT PEPTIDE

External links
Ncbi 1TR6_A

Tools