SVIB (P01793) Protein Card

General Information
Name SVIB
Alternative name(s) S6b,SNX-183
Organism Conus striatus (Striated cone)
Organism region Indo-Pacific
Organism diet piscivorous
Protein Type Wild type
Protein precursor SVIB precursor (862)
Notes SVIA and SVIB cause paralysis and death on intramuscular injection at 20 pmol/g (Ramilo et al.).

Classification
Conopeptide class conotoxin
Gene superfamily O1 superfamily
Cysteine framework VI/VII
Pharmacological family omega conotoxin

Sequence
CKLKGQSCRKTSYDCCSGSCGRSGKC(nh2)
Modified residues
positionsymbolname
27nh2C-term amidation
Sequence evidence protein level
Average Mass 2739.13
Monoisotopic Mass 2737.14
Isoelectric Point 11.55
Extinction Coefficient [280nm] 1490.00

Activity

IC50: Voltage-Gated Calcium Channels

TargetOrganismIC50AgonistRef
Cav2.2R. norvegicus1.09nMMVIIAMiljanich,G.P. et al. (1993)

Synthetic variants
SNX-202CKGSRGCSGSCCDYMLRSCSQGKLKC

References
Ramilo,C., Zafaralla,G.C., Nadasdi,L., Hammerland,L.G., Yoshikami,D., Gray,W.R., Kristipati,R., Ramachandran,J., Miljanich,G.P., Olivera,B.M. and Cruz,L.J. (1992) Novel alpha- and omega-conotoxins from Conus striatus venom Biochemistry 31:9919-9926
Nielsen,K.J., Thomas,L., Lewis,R.J., Alewood,P.F. and Craik,D.J. (1996) A consensus structure for omega-conotoxins with different selectivities for voltage-sensitive calcium channel subtypes: comparison of MVIIA, SVIB and SNX-202 J. Mol. Biol. 263:297-310

Internal links
Protein Precursor SVIB precursor (862)
Nucleic acids
Structure N-TYPE CALCIUM CHANNEL BLOCKER, OMEGA-CONOTOXIN MVIIA NMR, 15 STRUCTURES

External links
Ncbi 1MVJ_A, AAB23764

Tools