SVIA (P01794) Protein Card

General Information
Name SVIA
Alternative name(s) S6a,SNX-157
Organism Conus striatus (Striated cone)
Organism region Indo-Pacific
Organism diet piscivorous
Protein Type Wild type
Protein precursor SVIA precursor (863)
SVIA precursor (1227)
SVIA precursor (1228)
SVIA precursor (1236)
SVIA precursor (1239)
Notes SVIA and SVIB cause paralysis and death on intramuscular injection at 20 pmol/g (Ramilo et al.).

Classification
Conopeptide class conotoxin
Gene superfamily O1 superfamily
Cysteine framework VI/VII
Pharmacological family omega conotoxin

Sequence
CRSSGSOCGVTSICCGRCYRGKCT(nh2)
Modified residues
positionsymbolname
7O4-Hydroxyproline
25nh2C-term amidation
Sequence evidence protein level
Average Mass 2493.86
Monoisotopic Mass 2492.00
Isoelectric Point 12.26
Extinction Coefficient [280nm] 1490.00

Activity

IC50: Voltage-Gated Calcium Channels

TargetOrganismIC50AgonistRef
Cav2.2R. norvegicus1.46uMMVIIAMiljanich,G.P. et al. (1993)

References
Ramilo,C., Zafaralla,G.C., Nadasdi,L., Hammerland,L.G., Yoshikami,D., Gray,W.R., Kristipati,R., Ramachandran,J., Miljanich,G.P., Olivera,B.M. and Cruz,L.J. (1992) Novel alpha- and omega-conotoxins from Conus striatus venom Biochemistry 31:9919-9926

Internal links
Protein Precursor SVIA precursor (863)
SVIA precursor (1227)
SVIA precursor (1228)
SVIA precursor (1236)
SVIA precursor (1239)
Nucleic acids
Structure

External links
Ncbi AAB23763

Tools