Textile convulsant peptide (P01810) Protein Card

General Information
Name Textile convulsant peptide
Alternative name(s) TCP
Organism Conus textile (Cloth-of-gold cone)
Organism region Indo-Pacific
Organism diet molluscivorous
Protein Type Wild type
Notes Cause convulsion in mice. Bhatia 2012 found this peptide only without C-term amidation.

Classification
Conopeptide class conotoxin
Gene superfamily O1 superfamily
Cysteine framework VI/VII
Pharmacological family

Sequence
NCPYCVVYCCPPAYCEASGCRPP(nh2)
Modified residues
positionsymbolname
24nh2C-term amidation
Sequence evidence Unknown
Average Mass 2488.88
Monoisotopic Mass 2486.94
Isoelectric Point 7.88
Extinction Coefficient [280nm] 4470.00

References
Olivera,B.M., Rivier,J., Clark,C., Ramilo,C.A., Corpuz,G.P., Abogadie,F.C., Mena,E.E., Woodward,S.R., Hillyard,D.R. and Cruz,L.J. (1990) Diversity of Conus neuropeptides Science 249:257-263
Cruz,L.J., Ramilo,C.A., Corpuz,G.P. and Olivera,B.M. (1992) Conus peptides: phylogenetic range of biological activity Biol. Bull. 183:159
Bhatia,S., Kil,Y.J., Ueberheide,B., Chait,B.T., Tayo,L., Cruz,L., Lu,B., Yates,J.R. 3rd. and Bern,M. (2012) Constrained de novo sequencing of conotoxins. J. Proteome Res. 11:4191-4200
Dobson,R., Collodoro,M., Gilles,N., Turtoi,A., De Pauw,E. and Quinton,L. (2012) Secretion and maturation of conotoxins in the venom ducts of Conus textile. Toxicon 60:1370-1379

Internal links
Nucleic acids
Structure

External links
UniProtKB/Swiss-Prot P58845
Ncbi P58845

Tools