ImI [C2U,C8U] (P02478) Protein Card

General Information
Name ImI [C2U,C8U]
Organism synthetic construct
Protein Type Synthetic
Parent ImI

Classification
Conopeptide class conotoxin
Gene superfamily
Pharmacological family alpha conotoxin

Sequence
GUCSDPRUAWRC(nh2)
Modified residues
positionsymbolname
2USelenocystine (half)
8USelenocystine (half)
13nh2C-term amidation
Average Mass 1314.12
Monoisotopic Mass 1438.38
Isoelectric Point 10.99
Extinction Coefficient [280nm] 5500.00

Activity

IC50: Nicotinic acetylcholine receptors

TargetOrganismIC50nhillAgonistRef
α7R. norvegicus49nM+/-160.7200uM AchArmishaw,C.J. et al. (2006)

References
Armishaw,C.J., Daly,N.L., Nevin,S.T., Adams,D.J., Craik,D.J. and Alewood,P.F. (2006) Alpha-selenoconotoxins, a new class of potent alpha7 neuronal nicotinic receptor antagonists J. Biol. Chem. 281:14136-14143

Internal links
Nucleic acids
Structure SOLUTION STRUCTURE OF [SEC2,8]-IMI

External links
Ncbi 2BC7_A

Tools