ImI [C2U,C3U,C8U,C12U] (P02479) Protein Card

General Information
Name ImI [C2U,C3U,C8U,C12U]
Organism synthetic construct
Protein Type Synthetic
Parent ImI

Classification
Conopeptide class conotoxin
Gene superfamily
Pharmacological family alpha conotoxin

Sequence
GUUSDPRUAWRU(nh2)
Modified residues
positionsymbolname
2USelenocystine (half)
3USelenocystine (half)
8USelenocystine (half)
12USelenocystine (half)
13nh2C-term amidation
Average Mass 1276.70
Monoisotopic Mass 1526.27
Isoelectric Point 10.99
Extinction Coefficient [280nm] 5500.00

Activity

IC50: Nicotinic acetylcholine receptors

TargetOrganismIC50nhillAgonistRef
α7R. norvegicus50nM+/-68200uM AchArmishaw,C.J. et al. (2006)

References
Armishaw,C.J., Daly,N.L., Nevin,S.T., Adams,D.J., Craik,D.J. and Alewood,P.F. (2006) Alpha-selenoconotoxins, a new class of potent alpha7 neuronal nicotinic receptor antagonists J. Biol. Chem. 281:14136-14143

Internal links
Nucleic acids
Structure [SEC2,3,8,12]-IMI

External links
Ncbi 2BC8_A

Tools