Ac1.1b (P02485) Protein Card

General Information
Name Ac1.1b
Organism Conus achatinus
Organism region Indo-Pacific
Organism diet piscivorous
Protein Type Wild type
Protein precursor Ac1.1b precursor (571)
Ac1.1b precursor (545)
Ac1.1b precursor (2989)

Classification
Conopeptide class conotoxin
Gene superfamily A superfamily
Cysteine framework I
Pharmacological family alpha conotoxin

Sequence
NGRCCHPACGKHFSC(nh2)
Modified residues
positionsymbolname
16nh2C-term amidation
Sequence evidence nucleic acid level
Average Mass 1614.85
Monoisotopic Mass 1613.62
Isoelectric Point 11.81
Extinction Coefficient [280nm] NA

Activity

IC50: Nicotinic acetylcholine receptors

TargetOrganismIC50AgonistRef
α1β1δM. musculus101pM+/-6410uM AchLiu,L. et al. (2007)
α1β1γδM. musculus25.8nM+/-5.910uM AchLiu,L. et al. (2007)
α1β1;γM. musculus>50uM10uM AchLiu,L. et al. (2007)
α2β2R. norvegicus>5uM100uM AchLiu,L. et al. (2007)
α3β4R. norvegicus>50uM100uM AchLiu,L. et al. (2007)

Synthetic variants
Ac1.1b [Del1](nh2)CSFHKGCAPHCCRG

References
Yuan,D.D., Han,Y.H., Wang,C.G. and Chi,C.W. (2007) From the identification of gene organization of alpha conotoxins to the cloning of novel toxins Toxicon 49:1135-1149
Liu,L., Chew,G., Hawrot,E., Chi,C. and Wang,C. (2007) Two potent alpha3/5 conotoxins from piscivorous Conus achatinus. Acta Biochim. Biophys. Sin. (Shanghai) 39:438-444

Internal links
Protein Precursor Ac1.1b precursor (571)
Ac1.1b precursor (545)
Ac1.1b precursor (2989)
Nucleic acids
Structure

External links
Ncbi ABD48789, ABD33864, ABD33847

Tools