Lp1.1 (P02496) Protein Card

General Information
Name Lp1.1
Organism Conus leopardus
Organism region Indo-Pacific
Organism diet vermivorous
Protein Type Wild type
Protein precursor Lp1.1 precursor (119)
Lp1.1 precursor (543)
Notes LtIA from Conus leopardus has the same sequence as Lp1.1. The activity of LtIA for different nAChR subtypes was also characterized.

Classification
Conopeptide class conotoxin
Gene superfamily A superfamily
Cysteine framework I
Pharmacological family alpha conotoxin

Sequence
GCCARAACAGIHQELC(nh2)
Modified residues
positionsymbolname
17nh2C-term amidation
Sequence evidence nucleic acid level
Average Mass 1600.86
Monoisotopic Mass 1599.65
Isoelectric Point 8.31
Extinction Coefficient [280nm] NA

Activity

Percentage inhibition: Nicotinic acetylcholine receptors

TargetOrganism% inhibitionConcentrationAgonistRef
α1β1γδM. musculus5+/-101uM10uM AchPeng,C. et al. (2008)
α3β2R. norvegicus70+/-510uM100uM AchPeng,C. et al. (2008)
α3β4R. norvegicus0+/-510uM100uM AchPeng,C. et al. (2008)
α4β2R. norvegicus010uM100uM AchPeng,C. et al. (2008)
α4β4R. norvegicus2+/-510uM100uM AchPeng,C. et al. (2008)
α6/α3β2R. norvegicus40+/-101uM100uM AchPeng,C. et al. (2008)
α6/α3β4R. norvegicus0+/-210uM100uM AchPeng,C. et al. (2008)
α7R. norvegicus01uM100uM AchPeng,C. et al. (2008)

References
Yuan,D.D., Han,Y.H., Wang,C.G. and Chi,C.W. (2007) From the identification of gene organization of alpha conotoxins to the cloning of novel toxins Toxicon 49:1135-1149
Peng,C., Han,Y., Sanders,T., Chew,G., Liu,J., Hawrot,E., Chi,C. and Wang,C. (2008) alpha4/7-conotoxin Lp1.1 is a novel antagonist of neuronal nicotinic acetylcholine receptors. Peptides 29:1700-1707

Internal links
Protein Precursor Lp1.1 precursor (119)
Lp1.1 precursor (543)
Nucleic acids
Structure

External links
Ncbi ABD48792, AAS93424

Tools