Lp1.4 (P02497) Protein Card

General Information
Name Lp1.4
Organism Conus leopardus
Organism region Indo-Pacific
Organism diet vermivorous
Protein Type Wild type
Protein precursor Lp1.4 precursor (122)
Lp1.4 precursor (546)

Classification
Conopeptide class conotoxin
Gene superfamily A superfamily
Cysteine framework I
Pharmacological family alpha conotoxin

Sequence
GCCSHPACSGNHQELCD(nh2)
Modified residues
positionsymbolname
18nh2C-term amidation
Sequence evidence nucleic acid level
Average Mass 1755.88
Monoisotopic Mass 1754.60
Isoelectric Point 5.63
Extinction Coefficient [280nm] NA

Activity

Percentage inhibition: Nicotinic acetylcholine receptors

TargetOrganism% inhibitionConcentrationAgonistRef
α1β1γδM. musculus81+/-31uM10uM AchPeng,C. et al. (2010)
α3β2R. norvegicus36+/-310uM100uM AchPeng,C. et al. (2010)
α3β4R. norvegicus15+/-1410uM100uM AchPeng,C. et al. (2010)
α4β2R. norvegicus1+/-110uM100uM AchPeng,C. et al. (2010)
α4β4R. norvegicus010uM100uM AchPeng,C. et al. (2010)
α6/α3β2R. norvegicus48+/-31uM100uM AchPeng,C. et al. (2010)
α6/α3β4R. norvegicus22+/-610uM100uM AchPeng,C. et al. (2010)
α7R. norvegicus2+/-21uM100uM AchPeng,C. et al. (2010)

References
Yuan,D.D., Han,Y.H., Wang,C.G. and Chi,C.W. (2007) From the identification of gene organization of alpha conotoxins to the cloning of novel toxins Toxicon 49:1135-1149
Peng,C., Chen,W., Sanders,T., Chew,G., Liu,J., Hawrot,E. and Chi,C. (2010) Chemical synthesis and characterization of two α4/7-conotoxins. Acta Biochim. Biophys. Sin. (Shanghai) 42:745-753

Internal links
Protein Precursor Lp1.4 precursor (122)
Lp1.4 precursor (546)
Nucleic acids
Structure

External links
Ncbi AAS93427

Tools