SIA (P00025) Protein Card

General Information
Name SIA
Alternative name(s) S1a
Organism Conus striatus (Striated cone)
Organism region Indo-Pacific
Organism diet piscivorous
Protein Type Wild type

Classification
Conopeptide class conotoxin
Gene superfamily A superfamily
Cysteine framework I
Pharmacological family alpha conotoxin

Sequence
YCCHPACGKNFDC(nh2)
Modified residues
positionsymbolname
14nh2C-term amidation
Sequence evidence protein level
Average Mass 1455.65
Monoisotopic Mass 1454.50
Isoelectric Point 7.88
Extinction Coefficient [280nm] 1490.00

Activity

Percentage inhibition: Nicotinic acetylcholine receptors

TargetOrganism% inhibitionConcentrationRef
α1β1γδT. marmorata0Myers,R.A. et al. (1991)

References
Myers,R.A., Zafaralla,G.C., Gray,W.R., Abbott,J., Cruz,L.J. and Olivera,B.M. (1991) alpha-Conotoxins, small peptide probes of nicotinic acetylcholine receptors Biochemistry 30:9370-9377

Internal links
Nucleic acids
Structure

External links
UniProtKB/Swiss-Prot P28878
Ncbi AAB19853, P28878

Tools