Qc1.2 (P02511) Protein Card

General Information
Name Qc1.2
Alternative name(s) Qu-3
Organism Conus quercinus
Organism region Indo-Pacific
Organism diet vermivorous
Protein Type Wild type
Protein precursor Qc1.2 precursor (557)
Qc1.2 precursor (118)

Classification
Conopeptide class conotoxin
Gene superfamily A superfamily
Cysteine framework I
Pharmacological family alpha conotoxin

Sequence
QCCANPPCKHVNC(nh2)
Modified residues
positionsymbolname
14nh2C-term amidation
Sequence evidence nucleic acid level
Average Mass 1411.65
Monoisotopic Mass 1410.54
Isoelectric Point 10.12
Extinction Coefficient [280nm] NA

Activity

Percentage inhibition: Nicotinic acetylcholine receptors

TargetOrganism% inhibitionConcentrationAgonistRef
α1β1γδM. musculus01uM 10uM AchPeng,C. et al. (2009)
α3β2R. norvegicus65+/-1010uM100uM AchPeng,C. et al. (2009)
α3β4R. norvegicus35+/-1010uM 100uM AchPeng,C. et al. (2009)
α4β2R. norvegicus010uM100uM AchPeng,C. et al. (2009)
α4β4R. norvegicus010uM100uM AchPeng,C. et al. (2009)
α6/α3β2R. norvegicus101uM100uM AchPeng,C. et al. (2009)
α6/α3β4R. norvegicus010uM100uM AchPeng,C. et al. (2009)
α7R. norvegicus5+/-101uM100uM AchPeng,C. et al. (2009)

References
Peng,C., Chen,W., Han,Y., Sanders,T., Chew,G., Liu,J., Hawrot,E., Chi,C. and Wang,C. (2009) Characterization of a novel alpha4/4-conotoxin, Qc1.2, from vermivorous Conus quercinus. Acta Biochim. Biophys. Sin. (Shanghai) 41:858-864
Yao, G., Peng, C., Zhu, Y., Fan, C., Jiang, H., Chen, J., Cao, Y. and Shi, Q. (2019) High-Throughput Identification and Analysis of Novel Conotoxins from Three Vermivorous Cone Snails by Transcriptome Sequencing Marine drugs 17:193

Internal links
Protein Precursor Qc1.2 precursor (557)
Qc1.2 precursor (118)
Nucleic acids
Structure

External links
Ncbi AAS93423

Tools