Pu1.2 (P02520) Protein Card

General Information
Name Pu1.2
Organism Conus pulicarius
Organism region Indo-Pacific
Organism diet vermivorous
Protein Type Wild type
Protein precursor Pu1.2 precursor (568)
Notes Inhibits calcium currents in rat DRG neurons by 27%, via GABA-B receptor activation. (Carstens et al, 2016)

Classification
Conopeptide class conotoxin
Gene superfamily A superfamily
Cysteine framework I
Pharmacological family

Sequence
GGCCSYPPCIANNPLC(nh2)
Modified residues
positionsymbolname
17nh2C-term amidation
Sequence evidence nucleic acid level
Average Mass 1606.86
Monoisotopic Mass 1605.62
Isoelectric Point 8.09
Extinction Coefficient [280nm] 1490.00

Synthetic variants
Pu1.2(9-16)(nh2)CLPNNAIC
[Ser3, Ser9]Pu1.2(nh2)CLPNNAISPPYSCSGG
[Ser4]Pu1.2(1-9)(nh2)CPPYSSCGG

References
Yuan,D.D., Han,Y.H., Wang,C.G. and Chi,C.W. (2007) From the identification of gene organization of alpha conotoxins to the cloning of novel toxins Toxicon 49:1135-1149
Carstens,B.B., Berecki,G., Daniel,J.T., Lee,H.S., Jackson,K.A., Tae,H.S., Sadeghi,M., Castro,J., O (2016) Structure-Activity Studies of Cysteine-Rich a-Conotoxins that Inhibit High-Voltage-Activated Calcium Channels via GABA(B) Receptor Activation Reveal a Minimal Functional Motif. Angew. Chem. Int. Ed. Engl 55:4692-4696

Internal links
Protein Precursor Pu1.2 precursor (568)
Nucleic acids
Structure

External links
Ncbi ABD33870

Tools