Pu1.2 (P02520) Protein Card

General Information
Name Pu1.2
Organism Conus pulicarius
Organism region Indo-Pacific
Organism diet vermivorous
Protein Type Wild type
Protein precursor Pu1.2 precursor (568)
Notes Carstens et al, 2016 reported that Pu1.2 inhibited HVA calcium channel currents in rat DRG neurons by 27%.

Classification
Conopeptide class conotoxin
Gene superfamily A superfamily
Cysteine framework I
Pharmacological family alpha conotoxin

Sequence
GGCCSYPPCIANNPLC(nh2)
Modified residues
positionsymbolname
17nh2C-term amidation
Sequence evidence nucleic acid level
Average Mass 1606.86
Monoisotopic Mass 1605.62
Isoelectric Point 8.09
Extinction Coefficient [280nm] 1490.00

Synthetic variants
Pu1.2[C3S,C9S]GGSCSYPPSIANNPLC(nh2)
Pu1.2[del1-8]CIANNPLC(nh2)
Pu1.2[del10-16,C4S]GGCSSYPPC(nh2)

References
Yuan,D.D., Han,Y.H., Wang,C.G. and Chi,C.W. (2007) From the identification of gene organization of alpha conotoxins to the cloning of novel toxins Toxicon 49:1135-1149
Carstens,B.B., Berecki,G., Daniel,J.T., Lee,H.S., Jackson,K.A., Tae,H.S., Sadeghi,M., Castro,J., O (2016) Structure-Activity Studies of Cysteine-Rich a-Conotoxins that Inhibit High-Voltage-Activated Calcium Channels via GABA(B) Receptor Activation Reveal a Minimal Functional Motif. Angew. Chem. Int. Ed. Engl 55:4692-4696

Internal links
Protein Precursor Pu1.2 precursor (568)
Nucleic acids
Structure

External links
Ncbi ABD33870

Tools