SIVA (P02524) Protein Card

General Information
Name SIVA
Alternative name(s) S4a,Spastic peptide
Organism Conus striatus (Striated cone)
Organism region Indo-Pacific
Organism diet piscivorous
Protein Type Wild type
Protein precursor SIVA precursor (94)
SIVA precursor (3960)

Classification
Conopeptide class conotoxin
Gene superfamily A superfamily
Cysteine framework IV
Pharmacological family kappa conotoxin

Sequence
ZKSLVP(gSr)VITTCCGYDOGTMCOOCRCTNSC(nh2)
Modified residues
positionsymbolname
1ZPyroglutamic acid
7gSrglycosylated serine
17O4-Hydroxyproline
22O4-Hydroxyproline
23O4-Hydroxyproline
31nh2C-term amidation
Sequence evidence protein level
Average Mass 3189.63
Monoisotopic Mass 3187.27
Isoelectric Point NA
Extinction Coefficient [280nm] NA

References
Santos,A.D., McIntosh,J.M., Hillyard,D.R., Cruz,L.J. and Olivera,B.M. (2004) The A-superfamily of conotoxins: structural and functional divergence J. Biol. Chem. 279:17596-17606
Wang,C.Z., Jiang,H., Ou,Z.L., Chen,J.S. and Chi,C.W. (2003) cDNA cloning of two A-superfamily conotoxins from Conus striatus Toxicon 42:613-619
Craig,A.G., Zafaralla,G., Cruz,L.J., Santos,A.D., Hillyard,D.R., Dykert,J., Rivier,J.E., Gray,W.R., Imperial,J., DelaCruz,R.G., Sporning,A., Terlau,H., West,P.J., Yoshikami,D. and Olivera,B.M. (1998) An O-glycosylated neuroexcitatory conus peptide Biochemistry 37:16019-16025

Internal links
Protein Precursor SIVA precursor (94)
SIVA precursor (3960)
Nucleic acids
Structure

External links
Ncbi P0C828, AAN86573

Tools