BtX (P02526) Protein Card

General Information
Name BtX
Alternative name(s) BeTX
Organism Conus betulinus
Organism region Indo-Pacific
Organism diet vermivorous
Protein Type Wild type
Protein precursor BtX precursor (1106)
Notes BeTX acts on calcium activated potassium channels with an EC50 of 0.7 nm and a Hill coefficient of 0.88 (Fan et al.).

Classification
Conopeptide class conotoxin
Gene superfamily I2 superfamily
Cysteine framework XI
Pharmacological family kappa conotoxin

Sequence
CRA(Gla)GTYC(Gla)NDSQCCLN(Gla)CCWGGCGHOCR
HP(nh2)
Modified residues
positionsymbolname
4GlaGamma carboxylic glutamic acid
9GlaGamma carboxylic glutamic acid
18GlaGamma carboxylic glutamic acid
27O4-Hydroxyproline
32nh2C-term amidation
Sequence evidence protein level
Average Mass 3571.77
Monoisotopic Mass 3569.15
Isoelectric Point 6.36
Extinction Coefficient [280nm] 6990.00

References
Fan,C.X., Chen,X.K., Zhang,C., Wang,L.X., Duan,K.L., He,L.L., Cao,Y., Liu,S.Y., Zhong,M.N., Ulens,C., Tytgat,J., Chen,J.S., Chi,C.W. and Zhou,Z. (2003) A Novel Conotoxin from Conus betulinus, kappa -BtX, Unique in Cysteine Pattern and in Function as a Specific BK Channel Modulator J. Biol. Chem. 278:12624-12633

Internal links
Protein Precursor BtX precursor (1106)
Nucleic acids
Structure

External links

Tools