VcVA (P02540) Protein Card

General Information
Name VcVA
Alternative name(s) Vc5.1,Vc5a
Organism Conus victoriae
Organism region Indo-Pacific
Organism diet molluscivorous
Protein Type Wild type
Protein precursor VcVA precursor (1549)

Classification
Conopeptide class conotoxin
Gene superfamily T superfamily
Cysteine framework V
Pharmacological family

Sequence
CCPGKOCCRI(nh2)
Modified residues
positionsymbolname
6O4-Hydroxyproline
11nh2C-term amidation
Sequence evidence protein level
Average Mass 1090.35
Monoisotopic Mass 1089.43
Isoelectric Point 11.92
Extinction Coefficient [280nm] NA

Activity

Percentage inhibition: Somatostatin receptors

TargetOrganism% inhibitionConcentrationAgonistRef
sst3H. sapiens-10+/-1010 uM125I-[Tyr11]-somatostatin (0.05 nM)Petrel,C. et al. (2013)

References
Jakubowski,J.A., Keays,D.A., Kelley,W.P., Sandall,D.W., Bingham,J.P., Livett,B.G., Gayler,K.R. and Sweedler,J.V. (2004) Determining sequences and post-translational modifications of novel conotoxins in Conus victoriae using cDNA sequencing and mass spectrometry J Mass Spectrom 39:548-557

Internal links
Protein Precursor VcVA precursor (1549)
Nucleic acids
Structure

External links
Ncbi P69765

Tools