CVIA (P02548) Protein Card

General Information
Name CVIA
Alternative name(s) C6a,catus-C1b
Organism Conus catus
Organism region Indo-Pacific
Organism diet piscivorous
Protein Type Wild type
Protein precursor CVIA precursor (1597)
CVIA precursor (1195)
CVIA precursor (1197)
CVIA precursor (1200)

Classification
Conopeptide class conotoxin
Gene superfamily O1 superfamily
Cysteine framework VI/VII
Pharmacological family omega conotoxin

Sequence
CKSTGASCRRTSYDCCTGSCRSGRC(nh2)
Modified residues
positionsymbolname
26nh2C-term amidation
Sequence evidence protein level
Average Mass 2641.93
Monoisotopic Mass 2640.03
Isoelectric Point 12.10
Extinction Coefficient [280nm] 1490.00

Activity

IC50: Voltage-Gated Calcium Channels

TargetOrganismIC50AgonistRef
Cav2.1R. norvegicus850nMMVIICLewis,R.J. et al. (2000)
Cav2.2R. norvegicus560pMGVIALewis,R.J. et al. (2000)

References
Lewis,R.J., Nielsen,K.J., Craik,D.J., Loughnan,M.L., Adams,D.A., Sharpe,I.A., Luchian,T., Adams,D.J., Bond,T., Thomas,L., Jones,A., Matheson,J.L., Drinkwater,R., Andrews,P.R. and Alewood,P.F. (2000) Novel omega-conotoxins from Conus catus discriminate among neuronal calcium channel subtypes J. Biol. Chem. 275:35335-35344

Internal links
Protein Precursor CVIA precursor (1597)
CVIA precursor (1195)
CVIA precursor (1197)
CVIA precursor (1200)
Nucleic acids
Structure

External links
Ncbi P58917

Tools