TxO4 (P02556) Protein Card

General Information
Name TxO4
Organism Conus textile (Cloth-of-gold cone)
Organism region Indo-Pacific
Organism diet molluscivorous
Protein Type Wild type
Protein precursor TxO4 precursor (871)
TxO4 precursor (1103)
Notes This peptide was also found truncated from its forst twelve amino acids, resulting in a cysteine framework I peptide (Bhatia 2012).

Classification
Conopeptide class conotoxin
Gene superfamily O1 superfamily
Cysteine framework VI/VII
Pharmacological family

Sequence
YDCEPPGNFCGMIKIGPOCCSG(BTr)CFFACA
Modified residues
positionsymbolname
18O4-Hydroxyproline
23BTrBromotryptophan
Sequence evidence protein level
Average Mass 3206.50
Monoisotopic Mass 3203.09
Isoelectric Point 5.63
Extinction Coefficient [280nm] 1490.00

References
Lu,B.S., Yu,F., Zhao,D., Huang,P.T. and Huang,C.F. (1999) Conopeptides from Conus striatus and Conus textile by cDNA cloning Peptides 20:1139-1144
Bhatia,S., Kil,Y.J., Ueberheide,B., Chait,B.T., Tayo,L., Cruz,L., Lu,B., Yates,J.R. 3rd. and Bern,M. (2012) Constrained de novo sequencing of conotoxins. J. Proteome Res. 11:4191-4200

Internal links
Protein Precursor TxO4 precursor (871)
TxO4 precursor (1103)
Nucleic acids
Structure

External links
Ncbi Q9XZL1, AAD31917

Tools