Tx3h (P02565) Protein Card

General Information
Name Tx3h
Alternative name(s) TxMLKM-011
Organism Conus textile (Cloth-of-gold cone)
Organism region Indo-Pacific
Organism diet molluscivorous
Protein Type Wild type
Protein precursor Tx3h precursor (1472)
Tx3h precursor (629)
Notes This peptide was also found without C-terminal amidation but with a bromination of its tryptophan residue.

Classification
Conopeptide class conotoxin
Gene superfamily M superfamily
Cysteine framework III
Pharmacological family

Sequence
KFCCDSNWCHISDCECCY(nh2)
Modified residues
positionsymbolname
19nh2C-term amidation
Sequence evidence protein level
Average Mass 2152.39
Monoisotopic Mass 2150.68
Isoelectric Point 5.63
Extinction Coefficient [280nm] 6990.00

References
Corpuz,G.P., Jacobsen,R.B., Jimenez,E.C., Watkins,M., Walker,C., Colledge,C., Garrett,J.E., McDougal,O., Li,W., Gray,W.R., Hillyard,D.R., Rivier,J., McIntosh,J.M., Cruz,L.J. and Olivera,B.M. (2005) Definition of the M-conotoxin superfamily: characterization of novel peptides from molluscivorous Conus venoms Biochemistry 44:8176-8186
Ueberheide,B.M., Fenyƶ,D., Alewood,P.F. and Chait,B.T. (2009) Rapid sensitive analysis of cysteine rich peptide venom components. Proc. Natl. Acad. Sci. U.S.A. 106:6910-6915
Bhatia,S., Kil,Y.J., Ueberheide,B., Chait,B.T., Tayo,L., Cruz,L., Lu,B., Yates,J.R. 3rd. and Bern,M. (2012) Constrained de novo sequencing of conotoxins. J. Proteome Res. 11:4191-4200
Dobson,R., Collodoro,M., Gilles,N., Turtoi,A., De Pauw,E. and Quinton,L. (2012) Secretion and maturation of conotoxins in the venom ducts of Conus textile. Toxicon 60:1370-1379

Internal links
Protein Precursor Tx3h precursor (1472)
Tx3h precursor (629)
Nucleic acids
Structure

External links
Ncbi P0C1N6

Tools