GmIXA (P02576) Protein Card

General Information
Name GmIXA
Alternative name(s) Gm9.1,gm9a
Organism Conus gloriamaris
Organism region Indo-Pacific
Organism diet molluscivorous
Protein Type Wild type
Protein precursor GmIXA precursor (609)

Classification
Conopeptide class conotoxin
Gene superfamily P superfamily
Cysteine framework IX
Pharmacological family

Sequence
SCNNSCQSHSDCASHCICTFRGCGAVN(nh2)
Modified residues
positionsymbolname
28nh2C-term amidation
Sequence evidence nucleic acid level
Average Mass 2798.03
Monoisotopic Mass 2796.01
Isoelectric Point 8.15
Extinction Coefficient [280nm] NA

Synthetic variants
cyclic GmIXAPLGNVAGCGRFTCICHSACDSHSQCSNNCS

References
Miles,L.A., Dy,C.Y., Nielsen,J., Barnham,K.J., Hinds,M.G., Olivera,B.M., Bulaj,G. and Norton,R.S. (2002) Structure of a Novel P-superfamily Spasmodic Conotoxin Reveals an Inhibitory Cystine Knot Motif J. Biol. Chem. 277:43033-43040
Lirazan,M.B., Hooper,D., Corpuz,G.P., Ramilo,C.A., Bandyopadhyay,P., Cruz,L.J. and Olivera,B.M. (2000) The spasmodic peptide defines a new conotoxin superfamily Biochemistry 39:1583-1588

Internal links
Protein Precursor GmIXA precursor (609)
Nucleic acids
Structure STRUCTURE OF A NOVEL P-SUPERFAMILY SPASMODIC CONOTOXIN REVEALS AN INHIBITORY CYSTINE KNOT MOTIF

External links
Ncbi 1IXT_A, Q9GU57

Tools